exosomes and hair

Stem cell hair regrowth is much more than a simple transplant; it's a highly innovative process.  Considering a stem cell hair transplant? Read this first to help you make an informed decision. 

What Is Stem Cell Hair Transplant/Regrowth?

A stem cell hair transplant is sort of like a traditional hair transplant, but instead of eliminating a big number of hairs for transplanting to the hair loss area, stem cell hair transplants eliminate a small sample of skin from which the doctor harvests hair follicles. It's an extremely innovative procedure that encourages your own natural hair growth using your own body's stem cells.

The follicles then become replicated in a laboratory and the doctor implants them back into your scalp in the hair loss areas, allowing hair to grow right where they took the follicles from and where they're transplanted.

However, unlike other hair transplant procedures that focus on hair follicle relocation, stem cell hair therapy is made for restoring natural hair follicle growth to achieve long-lasting results.

The stem cells of your body are responsible for repairing and healing tissues. They're important building blocks that can turn themselves into any cell type. The fat layer below your skin is where many mesenchymal stem cells reside. These mesenchymal stem cells, thanks to innovative technology, can be harvested so doctors can utilize their regenerative qualities. When your stem cells are introduced into thinning hair areas, they can help with hair follicle regeneration to restore adequate hair growth.

What Is an Exosome?

Exosomes are the most recent generation of bioactive naturally amnion-based products for the treatment of a patient's hair loss or thinning. They work like paracrine effectors, where they signal or stimulate nearby cells. This stimulating effect on cells and tissues is due to biochemical stimulating contents being transferred from one cell to the next. These messengers are known as microvesicles and exosomes, collectively referred to as extracellular vesicles (EVs).

Exosomes don't contain any nucleus or DNA and are about 1000 times smaller than regular cells. They are 30-100 nanometer tiny nanoparticles involved in intercellular signaling and cell-to-cell communication. They're secreted by most body cell types and contain both microRNA (miRNA) and messenger RNA (mRNA).

What are Exosomes for Hair Loss?

Exosomes for hair restoration have just recently been researched. It wasn't until 2019 that researchers and doctors decided this treatment had huge potential. Numerous new applications may appear with further clinical trials.

Present Delivery Systems

There are two delivery methods currently being researched:

  • First is an injection after producing a serum. The serum is the same as many blood treatments, but needs additional manufacturing and filtration to selectively isolate and net the exosomes. Beneficial growth factors will obviously be in the serum, but won't be the focus.
  • Second is another injection, like the first, but instead of being a traditional injection, it almost resembles micro-needling, which is scalp puncturing to enhance hair retention. The needles in this second exosome delivery method are much smaller.

Research shows both micro-needling and injection are viable. Results, however, are favoring micro-needling.

What Are Mesenchymal Cells?

These are adult stem cells that are isolated from various sources that could differentiate into other cell types. In human beings, these sources are:

  • Umbilical cord tissue (Wharton's Jelly)
  • Bone marrow
  • Amniotic fluid (a fluid that surrounds a fetus)
  • Fat (adipose tissue)

Stromal stem cells or mesenchymal stem cells (MSCs) can differentiate into many cell types within the body, which include:

  • Muscle cells
  • Bone cells
  • Skin cells
  • Cartilage
  • Corneal cells
  • Neural cells

Everybody has mesenchymal stem cells. MSCs are mainly found in each person's bone marrow and stay dormant until they're called upon for promoting body healing. They age as the individual ages and their effectiveness and number is reduced over the years.

What Is XoFlo?

XoFlo is a placental-derived exosome product carrying a milieu of inflammatory modulating proteins. Exosomes stimulate stem cell communication and activity. When XoFlo is in a topical application, it can help in the reconstruction and repair of skin tissue.

XoFlo exosomes come from placental-derived MSCs. They're purified through the use of a proprietary filtration process. They're not cells, but rather microvesicles that don't contain DNA or nucleus. XoFlo is seen as a very pure form of cellular therapy available since it offers wound healing and tissue stimulation by triggering your own regenerative cells to become active.

What Is the Exosome Therapy Process With XoFlo? 

By nature, regenerative cells work to repair, heal, stimulate and restore tissues and cells. The hair follicle is vulnerable to miniaturization by hormonal and genetic effects from DHT.

The EV's tiny size allows for simple injection into the superficial scalp dermis with local anesthesia. The doctor can use common autologous scaffolds such as A-Cell or HD-PRP since they help in cell migration and cell retention. The doctor performs the procedure in the same way as other simple out-patient office procedures like HD-PRP injections.

By injecting growth factors and exosomes, it's been clinically shown to help regrow and regenerate hair as a therapy for loss of hair in both women and men in the earlier hair loss stages.

The doctor will inject XoFlo in the same way as PRP hair loss treatments. They can use a 2.5 cc or 5 cc treatment depending on how much hair loss there is. First, he’ll provide local anesthesia to the area to numb the area.  He’ll then inject the preparation into the scalp with tiny needles into the thinning scalp areas just under the skin.

They'll space the injections carefully to maximize the effect of the treatment with concentrated protein factors that are known for promoting hair growth. Both women and men with most patterns of hair loss can benefit from this treatment. Since the preparation is acellular, the areas being treated don't show any redness or inflammation after treatment.

Number of Treatments

Typically, patients should begin seeing the effects within four weeks of the first treatment. Many patients with inflammation, pain, strains, or degenerative diseases experience substantial improvement after one treatment. Since all patients are different, it's essential you refer to your doctor for the proper treatment plan that will meet your own individual requirements and to see if you're a good candidate for XoFlo.

What to Expect

Your doctor will advise about their exact procedures and protocols in preparation of your XoFlo treatment. Most individuals go back to normal day-to-day function post-procedure, but it's suggested you avoid strenuous exercise right after your procedure to allow the treatment to be successful. Your doctor will talk with you about the post-procedure protocol as well as the proper follow-up.

Are you a Good Candidate for XoFlo?

XoFlo can be used in both early and later hair loss stages. Also, it can be used together with hair transplant or PRP. You may be an ideal candidate for XoFlo if:

  • You've been told you're not a good candidate for hair transplant
  • You're receding or thinning
  • You're a little hesitant to make a commitment to a hair transplant
  • You have female pattern baldness
  • u require an additional treatment after hair transplant or PRP
  • You have Traction Alopecia that's due to thinning (not bald) scalp areas
  • You're a woman with generalized thinning

The tolerability and safety of XoFlo are known, but no case reports or scientific studies are available in individuals who have had hair restoration, so the efficacy of XoFlo can't be determined. It's an extremely new product that has great promise and hope. But, this FDA-approved product comes with no guarantee of success and each patient varies in their clinical response to this medical therapy. Hair loss treatment with novel regenerative treatments is exciting with tolerability and safety well-established. 

Consult With Bradford Patt, MD to Talk About Stem Cell Hair Transplant

Dr. Patt is greatly respected and admired by his peer physicians, and has been recognized as a Super Doctor for the last 13 years in Houston. He is cherished by his patients, and offers personalized consultations.  Dr. Patt and his entire team at the Houston Center for Facial Plastic Surgery (HCFPS) are dedicated to the safety and wellbeing of our patients and employees, and now offer telemedicine services.

Contact our office to set up a consultation with Dr. Bradford Patt to see if your current medical condition will qualify for XoFlo treatment. If so, we'll advise you of the best treatment plan associated with your condition.

 

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